1-Pyrrolidinecarboxylic acid, 3-(4-fluorophenyl)-4-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R,4R)-
tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate
CAS: 939823-88-8
Molecular Formula: C16H22FNO3
1-Pyrrolidinecarboxylic acid, 3-(4-fluorophenyl)-4-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R,4R)- - Names and Identifiers
1-Pyrrolidinecarboxylic acid, 3-(4-fluorophenyl)-4-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R,4R)- - Physico-chemical Properties
| Molecular Formula | C16H22FNO3 |
| Molar Mass | 295.35 |
1-Pyrrolidinecarboxylic acid, 3-(4-fluorophenyl)-4-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R,4R)- - Introduction
tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate is an organic compound with the chemical formula C15H21NO3F.
Nature:
-Appearance is white crystalline powder
-Can be dissolved in an inert solvent, such as dimethylformamide (DMF) or dichloromethane
-Has a lower melting point and boiling point
-trans configuration makes the molecule present a specific spatial structure
Use:
-As an organic synthesis intermediate, it can be used to synthesize drugs or other compounds
-Can be used as a raw material for insecticides and fungicides
-In chemical research, used to synthesize various biologically active compounds
Method:
tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate can be synthesized by the following steps:
1. 4-fluorophenyl tert-butanol was prepared by reacting 4-fluoroacetophenone with tert-butanol.
2. 4-fluorophenyl tert-butyl alcohol was reacted with benzyl magnesium bromide to prepare 4-fluorophenyl tert-butyl ketone.
3. 4-Fluorophenyl tert-butyl ketone is reacted with ethylenediamine to produce 4-fluorophenyl tert-butyl acid ethylenediamine salt.
4. The ethylenediamine salt of 4-fluorophenyl tert-butyl acid is reacted with methanol to obtain the tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate.
Safety Information:
Although tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate have certain uses in chemical research and synthesis, the following precautions should be followed:
-Wear appropriate protective measures such as gloves, safety glasses and a protective mask when handling this compound
-Avoid inhalation or contact with skin or eyes
-Maintain a well-ventilated laboratory environment when using or storing compounds
-Adhere to national and regional regulations for safe handling of chemicals and proper disposal of waste
Please note that this information is for reference only. The specific preparation method and safe operation should be evaluated and corresponding measures should be taken according to the specific situation and laboratory conditions.
Nature:
-Appearance is white crystalline powder
-Can be dissolved in an inert solvent, such as dimethylformamide (DMF) or dichloromethane
-Has a lower melting point and boiling point
-trans configuration makes the molecule present a specific spatial structure
Use:
-As an organic synthesis intermediate, it can be used to synthesize drugs or other compounds
-Can be used as a raw material for insecticides and fungicides
-In chemical research, used to synthesize various biologically active compounds
Method:
tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate can be synthesized by the following steps:
1. 4-fluorophenyl tert-butanol was prepared by reacting 4-fluoroacetophenone with tert-butanol.
2. 4-fluorophenyl tert-butyl alcohol was reacted with benzyl magnesium bromide to prepare 4-fluorophenyl tert-butyl ketone.
3. 4-Fluorophenyl tert-butyl ketone is reacted with ethylenediamine to produce 4-fluorophenyl tert-butyl acid ethylenediamine salt.
4. The ethylenediamine salt of 4-fluorophenyl tert-butyl acid is reacted with methanol to obtain the tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate.
Safety Information:
Although tert-butyl trans-3-(4-fluorophenyl)-4-(hydroxymethyl)pyrrolidine-1-carboxylate have certain uses in chemical research and synthesis, the following precautions should be followed:
-Wear appropriate protective measures such as gloves, safety glasses and a protective mask when handling this compound
-Avoid inhalation or contact with skin or eyes
-Maintain a well-ventilated laboratory environment when using or storing compounds
-Adhere to national and regional regulations for safe handling of chemicals and proper disposal of waste
Please note that this information is for reference only. The specific preparation method and safe operation should be evaluated and corresponding measures should be taken according to the specific situation and laboratory conditions.
Last Update：2024-04-09 15:18:04
